In a weighted Sobolev space on the whole real axis, we obtain the sufficient conditions for the well-posed and unique solvability of m,n order operator-differential equations. These conditions were formulated only by the operator coefficients of the considered equation. According to the values of m,n the operator-differential equation has complicated and multiple characteristics. In addition, by using the main part of the equation, the norms of the operators of intermediate derivative were estimated. We deduce the relationship between the exponent of the weight and the lower bound of the spectrum of the operator of the main part of the equation. As an applied result of this paper, we formulated a problem for higher-order partial differential equations and we provided an alternative method for obtaining the regular solvability of operator pencil.
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